Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 134, Issue 6, Pages 873-879Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPPPR57HNJMSLZ
Keywords
Carbonic anhydrase IX; Renal cell carcinoma; Clear cell renal cell carcinoma
Categories
Funding
- Dana-Farber/Harvard Cancer Center Kidney SPORE National Cancer Institute (Bethesda, MD) [P50CA101942]
- Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientific (IRCCS), Rome, Italy
- American-Italian Cancer Foundation
Ask authors/readers for more resources
Carbonic anhydrase IX (CAD), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation rend cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas,. 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P < .01) and primary (P < .01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available