Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 130, Issue 2, Pages 178-185Publisher
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/PNXUKA1CFJMVGCN1
Keywords
peripheral T-cell lymphoma; extranodal NK/T-cell lymphoma; cytogenetics; fluorescence in situ hybridization; T-cell receptor; TCL1; isochromosome 7q
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Translocations involving the T-cell receptor (TCR) and TCL1 genes occur in T-cell precursor lymphoblastic leukemia/lymphoma and prolymphocytic leukemia; isochromosome 7q has been associated with hepatosplenic T-cell lymphoma. However, the incidence of these abnormalities in peripheral T-cell lymphomas (PTCLs) as a whole has not been well defined. We studied genetic abnormalities in 124 PTCLs seen at the Mayo Clinic, Rochester, MN, between 1987 and 2007. Tissue microarrays were screened using 2-color break-apart fluorescence in situ hybridization probes flanking the TCR alpha (TCRA, 14q11), TCRa (TCRB, 7q35), and TCR gamma (TCRG, 7p15) genes and the TCL1 gene (14q32). Isochromosome AI was analyzed by using a 2-color probe to 7p and 7q32.1. Translocations involved TCRA in 3 (2.9%) of 102 cases and TCRB in 1 (1%) of 88. Isochromosome 7q was detected in 2 cases of extranodal NK/T-cell lymphoma, nasal type, and 2 cases of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma. One of the latter cases also had a translocation of TCRA, and,further studies confirmed a novel t(5;14) translocation.
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