Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 95, Issue 6, Pages 1477-1486Publisher
AMER SOC NUTRITION-ASN
DOI: 10.3945/ajcn.111.026955
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Categories
Funding
- Look AHEAD [U01DK056992-11SI, DK072497]
- Department of Health and Human Services through NIH [DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, DK56992]
- Johns Hopkins Medical Institutions Bayview General Clinical Research Center [M01RR02719]
- Massachusetts General Hospital Mallinckrodt General Clinical Research Center [M01RR01066]
- University of Colorado Health Sciences Center General Clinical Research Center [M01RR00051]
- Clinical Nutrition Research Unit [P30 DK48520]
- University of Tennessee at Memphis General Clinical Research Center [M01RR0021140]
- University of Pittsburgh General Clinical Research Center [M01RR000056 44]
- NIH [DK072497, DK 046204]
- University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs
- Frederic C Banter General Clinical Research Center [M01RR01346]
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Background: Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear. Objective: The objective was to determine the association between obesity susceptibility loci and dietary intake. Design: The association of GWAS-identified obesity risk alleles (FTO, MC4R, SH2B1, BDNF, INSIG2, TNNI3K, NISCH-STAB1, MTIF3, MAP2K5, QPCTL/GIPR, and PPARG) with dietary intake, measured through food-frequency questionnaires, was investigated in 2075 participants from the Look AHEAD (Action for Health in Diabetes) clinical trial. We adjusted for age, sex, population stratification, and study site. Results: Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001) an effect that persisted after adjustment for body weight (P = 0.004). Risk variants within BDNF were significantly associated with more servings from the dairy product and the meat, eggs, nuts, and beans food groups (P <= 0.004). The risk allele at SH2BI rs4788099 was significantly associated with more servings of dairy products (P = 0.001), whereas the risk allele at TNNI3K rs1514176 was significantly associated with a lower percentage of energy from protein (P = 0.002). Conclusion: These findings suggest that obesity risk loci may affect the pattern and content of food consumption among overweight or obese individuals with type 2 diabetes. The Look AHEAD Genetic Ancillary Study was registered at clinicaltrials.gov as NCT01270763 and the Look AHEAD study as NCT00017953. Am J Clin Nutr 2012;95:1477-86.
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