Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 96, Issue 1, Pages 188-195Publisher
ELSEVIER SCIENCE INC
DOI: 10.3945/ajcn.112.035683
Keywords
-
Categories
Funding
- Australian National Health and Medical Research Council (NHMRC) [437015, 607358]
- Australian NHMRC Dora Lush Biomedical Research Scholarship
- Victorian Government
Ask authors/readers for more resources
Background: There are multiple potential regulators of neonatal vitamin D status of environmental, genetic, and epigenetic origins. The relation between these factors and circulating neonatal vitamin D has yet to be fully characterized. Objective: The aim of this study was to examine the relative contribution of genetic factors, maternal circulating 25-hydroxyvitamin D [25(OH)D] concentrations, and the placental methylation level of the gene that encodes the primary catabolic enzyme of active vitamin D [25(OH)D-24-hydroxylase encoded by CYP24A1] to neonatal 25(OH)D concentrations. Design: We used the classical twin study design to determine the genetic contribution to neonatal 25(OH)D. A total of 86 twin pairs (32 monozygotic and 54 dizygotic twin pairs) were included in this study. Serum 25(OH)D was measured by using a 25(OH)D kit. CYP24A1 promoter DNA methylation was measured by means of matrix-assisted laser desorption time-of-flight mass spectrometry. Results: Maternal and neonatal 25(OH)D showed a strong association (R-2 = 0.19). Monozygotic and dizygotic within-pair serum 25(OH)D correlations were similar (R-2 = 0.71 and 0.67, respectively), which suggested no genetic effect. Placental CYP24A1 methylation did not show an association with maternal or neonatal 25(OH)D concentrations. Conclusions: Our results suggest that maternal circulating 25(OH)D is the most significant regulator of neonatal circulating 25(OH)D concentrations, with underlying genetic factors playing a limited role. The placental methylation of the CYP24A1 promoter appears subject to a genetic influence, although no evidence of a relation between the methylation level of this gene and circulating maternal or neonatal 25(OH)D was apparent. Am J Clin Nutr 2012; 96:188-95.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available