Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 93, Issue 3, Pages 494-499Publisher
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.110.003251
Keywords
-
Categories
Funding
- Spanish Ministry of Science and Innovation (MICINN) [AGL2004-04958, AGL2005-03722, AGL2008-02811]
- CSIC
Ask authors/readers for more resources
Background: The nature of dietary fats and fasting concentrations of triglycerides affect postprandial hypertriglyceridemia and glucose homeostasis. Objectives: The objectives were to examine the effects of meals enriched in monounsaturated fatty acids (MUFAs) or saturated fatty acids (SFAs) on postprandial lipid, glucose, and insulin concentrations and to examine the extent of beta cell function and insulin sensitivity in subjects with high fasting triglyceride concentrations. Design: Fourteen men with fasting hypertriglyceridemia and normal glucose tolerance were given meals (approximate to 10 kcal/kg body weight) containing MUFAs, SFAs, or no fat. Blood samples were collected at baseline and hourly over 8 h for analysis. Results: The high-fat meals significantly increased postprandial concentrations of triglycerides, nonesterified fatty acids, and insulin and postprandial indexes of beta cell function. However, postprandial indexes of insulin sensitivity decreased significantly. These effects were significantly attenuated with MUFAs relative to SFAs. Conclusions: MUFAs postprandially buffered beta cell hyperactivity and insulin intolerance relative to SFAs in subjects with high fasting triglyceride concentrations. These data suggest that, in contrast with SFAs, MUFA-based strategies may provide cardiovascular benefits to persons at risk by limiting lipid and insulin excursions and may contribute to optimal glycemic control after meal challenges. Am J Clin Nutr 2011;93:494-9.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available