Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 91, Issue 5, Pages 1430S-1432SPublisher
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.2010.28674B
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- PHS HHS [U01 HE040657] Funding Source: Medline
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This article provides a review of how the challenge of bioavailability was approached in establishing the Dietary Reference Intakes, with a special focus on folic acid, vitamin B-12, beta-carotene, iron, selenium, and zinc, the targeted micronutrients for this workshop. In a future perspective, the necessity of having a clear working definition of bioavailability is emphasized. The bioavailability of micronutrients should be considered, with advantage, under subheadings determined by the broad factors that affect bioavailability. Special emphasis is given to giving greater and specific attention to factors involved in the maintenance of homeostasis. These factors, it is argued, are best considered separately from even a broad definition of bioavailability and have the potential to provide new insights into some micronutrient requirements. Am J Clin Nutr 2010; 91(suppl):1430S-2S.
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