Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 2, Pages 137-141Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2460
Keywords
-
Categories
Funding
- NCI NIH HHS [T32 CA070083-08, T32 CA070083-07, T32 CA070083, T32 CA070083-06] Funding Source: Medline
- NIAID NIH HHS [R37 AI012184-31, R01 AI048125-03, R37 AI012184-26, R37 AI012184, R01 AI048125, R37 AI012184-29, R37 AI012184-24, R01 AI048125-04, R01 AI048125-02, R37 AI012184-27, R37 AI012184-25, R01 AI048125-06A2, R01 AI048125-01, R37 AI012184-30, R37 AI012184-28, R01 AI048125-05, R37 AI012184-24S1] Funding Source: Medline
Ask authors/readers for more resources
Studies of osteopontin (OPN)-dependent regulation of immune responses have focused on the cytokine activities of the secreted form of this protein. Recent evidence has revealed that an intracellular form of OPN expressed by dendritic cells regulates the expression of pro-inflammatory cytokines and the differentiation of T helper (T-H)-cell lineages. In this Opinion article, we discuss the properties of both OPN isoforms and their respective contributions to the immune response. We propose that cell-type-specific expression of secreted and intracellular OPN regulates the development of distinct effector T-H cells, including that of T(H)1 and T(H)17 cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
