Journal
AMERICAN JOURNAL OF CARDIOLOGY
Volume 109, Issue 6, Pages 881-888Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2011.11.012
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Funding
- Children's Hospital Foundation, Omaha, Nebraska
- American College of Cardiology Foundation, Washington, DC
- Edna Ittner Pediatric Foundation, Omaha, NE, USA
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The systemic right ventricle (RV) in congenital heart disease is susceptible to progressive dilation and dysfunction. A 2-dimensional echocardiographic means for serial monitoring of the RV would be of great value in this clinical setting. We used 2-dimensional echocardiography with knowledge-based reconstruction (2DE-KBR) for evaluation of systemic RV. Patients with d-transposition of great arteries repaired with an atrial switch and without implanted pacemakers were prospectively recruited for same-day 2DE-KBR and cardiac magnetic resonance (CMR) imaging. RV images were acquired in various 2-dimensional imaging planes using a 3-dimensional space-localizing device attached to the imaging transducer and 3-dimensional reconstruction was performed. RV end-diastolic volume, end-systolic volume, and ejection fraction (EF) were calculated and compared to volumetric CMR analysis. Fifteen patients (7 women, 8 men, 24 +/- 7 years old, weight 67 +/- 12 kg) were studied. There was good agreement of 2DE-KBR and CMR measurements. Mean RV end-diastolic volume was 221 +/- 39 ml with 2DE-KBR and 231 +/- 35 ml with CMR (r = 0.80); mean end-systolic volume was 129 +/- 35 ml with KBR and 132 +/- 30 ml with CMR (r = 0.82), and EF was 42 +/- 10% with KBR and 43 +/- 7% with CMR (r = 0.86). For 2DE-KBR mean interobserver variabilities were 4.6%, 2.6%, and 4.3%; intra-observer variabilities were 3.2%, 3.1%, and 2.3%, respectively, for end-diastolic volume, end-systolic volume, and EF. In conclusion, this study demonstrates the clinical feasibility of quantifying systemic RV volumes and function using 2DE-KBR in adolescents and young adults with repaired d-transposition of great arteries and good agreement of measurements with CMR. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109:881-888)
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