Journal
YEAST
Volume 26, Issue 2, Pages 125-138Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/yea.1657
Keywords
transposon; nucleolus; organization; genome; architecture; domain
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Funding
- Royal Society Marsden Fund
- Maurice and Phyllis Paykel Trust
- Auckland Medical Research Foundation
- NZ Lottery Health
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The spatial organization of the chromosomes is crucial for gene expression and development. Inter- and intrachromosomal interactions form a crucial part of this epigenomic regulatory system. Here we use circular chromosome conformation capture-on-chip (4C) to identify interactions between repetitive and non-repetitive loci within the yeast genome. The interacting regions occur in non-randomly distributed clusters. Furthermore, the SIR2 histone deacetylase has opposing roles in the organization of the inter- or intrachromosomal interactions. These data establish a dynamic domain model for yeast genome organization. Moreover, they point to the repeated elements playing a central role in the dynamic organization of genome architecture. Copyright (C) 2009 John Wiley & Sons, Ltd.
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