Journal
AMERICAN JOURNAL OF CARDIOLOGY
Volume 103, Issue 4, Pages 471-475Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2008.09.104
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- Chang Gong University, TaoyLian, Taiwan [CMRPD160312, CMRPD160231]
- National Science Council of Taiwan, Taipei, Taiwan [NSC97-2320-B-182-015-MY3, NSC96-2320-B-182A-003-MY3, NSC96-232013-182-015-MY3]
- Ministry of Education of Taiwan, Taipei [EMRPD160241]
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Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 +/- 9.2 vs 47.3 +/- 16.6 U/g hemoglobin; p <0.001). There was a significant inverse correlation between GPX-1 activity and acute myocardial infarction incidence (p = 0.032). In addition, plasma vitamin E inversely correlated with acute myocardial infarction incidence (p = 0.017). The incidence of acute myocardial infarction increased only in patients with low plasma vitamin E and low erythrocytic GPX-1 activity, but not in those with high vitamin E and low GPX-1 activity, low vitamin E and high GPX-1 activity, or high vitamin E and high GPX-1 activity. In conclusion, acute myocardial infarction incidence significantly increased in patients with a concomitant decrease in plasma vitamin E and erythrocytic GPX-1 activity, suggesting that both GPX-1 and vitamin E may be valuable markers for monitoring cardiovascular events, particularly when used in combination. (c) 2009 Elsevier Inc. (Am J Cardiol 2009;103:471-475)
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