Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 39, Issue 3, Pages 395-404Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-008-0636-9
Keywords
Methylphenidate; Pervasive developmental disorders; Hyperactivity; Autism spectrum disorder
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Funding
- NCRR NIH HHS [M01 RR-00750, M01 RR000750, M01 RR000052, M01 RR000034, M01 RR006022, M01 RR-00052, M01 RR-00034, M01 RR-06022] Funding Source: Medline
- NIDA NIH HHS [N01MH80011] Funding Source: Medline
- NIMH NIH HHS [MH-01805, K23 MH001883-05, K23 MH068627, N01 MH-70009, N01 MH-70001, MH-68627, T32 MH018372, N01 MH-70070, N01 MH 80011, 5 T32 MH18372, U01 MH070009, K24 MH001805] Funding Source: Medline
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This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.
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