Journal
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
Volume 24, Issue 3, Pages 258-266Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317509332093
Keywords
mild cognitive impairment; Alzheimer's disease; eye tracking; early diagnosis; visual paired comparison; preferential looking
Categories
Funding
- National Institute of Health [AG 025588]
- Yerkes Base [RR00165]
- Robert W. Woodruff Health Science Award
- Emory University
- Atlanta VAMC Merit Review award
- Georgia Research Alliance
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The authors present findings from a behavioral task (visual paired comparison) using infrared eye-tracking that could potentially be useful in predicting the onset of Alzheimer's disease. Delay intervals of 2 seconds and 2 minutes were used between the initial viewing of a picture and when the picture was displayed alongside a novel Picture. Eye-tracking revealed that at the 2-second delay, 6 patients with mild cognitive impairment, 15 matched control participants (normal control), and 4 neurological control participants with Parkinson's disease performed comparably, viewing the novel picture greater than 71% of the time. When the delay increased to 2 minutes, patients with mild cognitive impairment viewed the novel picture only 53% of the time (P < .05), while control participants and participants with Parkinson's disease remained above 70%. These findings demonstrate the usefulness of this task for assessing normal as well as impaired memory function.
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