Journal
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
Volume 23, Issue 2, Pages 162-166Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317507312624
Keywords
MCI Screen; MMSE; Neuroimaging; early detection; mild cognitive impairment; Alzheimer's disease and related disorders
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Early detection of Alzheimer's disease and related disorders in Japan is increasingly important. The Mild In. Cognitive Impairment Screen (MCIS)-derived from the National Institute of Aging CERAD neuropsychologic batter)-differentiates normal aging from MCI and mild dementia with 97.3% and 99% accuracy, respectively. The Japanese MCIS (JMCIS), Mini-Mental State Examination (MMSE), quantitative SPECT (qSP), and quantitative MRI (qMRI) were used to classify 63 Outpatients at Fukuoka University Hospital who were either normal or bad MCI based on Clinical Dementia Rating scores of 0 and 0.5, respectively Performance statistics for the JMCIS, MMSE, qSP, and qMRI were, respectively: (1) accuracy = 0.964., 0.768, 0.722, 0.733; (2) sensitivity = 0.958, 0.792, 0.688, 0.700; (3) specificity = 1.000, 0.625, 1.000, 1.000; and (4) K validity = 0.813, 0.420, 0.296, 0.308. This initial study shows negligible differences between the English and Japanese MCIS, supporting its potential use for early detection in Japan.
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