Journal
INTELLIGENCE
Volume 37, Issue 2, Pages 192-198Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.intell.2008.10.009
Keywords
Intelligence; N-acetylaspartate; Gray matter; White matter; Sex differences
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Funding
- NCRR NIH HHS [P20 RR021938, P20 RR021938-01A2] Funding Source: Medline
- NIBIB NIH HHS [R01 EB006841, R01 EB020407] Funding Source: Medline
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Proton magnetic resonance spectroscopy (H-1-MRS) is a technique for the assay of brain neurochemistry in vivo. N-acetylaspartate (NAA), the most prominent metabolite visible within the 1H-MRS spectrum, is found primarily within neurons. The current study was designed to further elucidate NAA-cognition relationships, particularly whether such relationships are moderated by sex, or tissue type (gray or white matter). We administered standard measures of intelligence to 63 young, healthy subjects and obtained spectroscopic imaging data within a slab of tissue superior to the lateral ventricles. We found that lower NAA within right anterior gray matter predicted better performance VIQ (F=6.83, p=.011, r(2)=.10), while higher NAA within the right posterior gray matter region predicted better PIQ (F=8.175, p=.006, r(2) =.12). These findings add to the small but growing body of literature linking brain biochemistry to intelligence in normal healthy subjects using H-1-MRSI. (C) 2008 Elsevier Inc. All rights reserved.
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