Journal
INTERNATIONAL JOURNAL FOR ION MOBILITY SPECTROMETRY
Volume 12, Issue 1, Pages 33-37Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s12127-009-0016-y
Keywords
Ion mobility spectrometry; Electrospray ionization; High resolution; Pharmaceuticals; Explosives; Irinotecan
Categories
Funding
- U.S. Food and Drug Administration [1R43FD003502-01]
Ask authors/readers for more resources
Current commercially available ion mobility spectrometers are intended for the analysis of chemicals in the gas phase. Sample introduction methods, such as direct air sampling, a GC injector or a thermal desorber, are commonly an integral part of these instruments. This paper describes an electrospray ionization ion mobility spectrometer system that allows direct introduction of samples in solution phase. This allows direct analysis of non-volatile organic and biological samples, and avoids decomposition of thermally liable samples, providing reliable chemical identification. In addition, the new ion mobility spectrometer allows mobility analysis with high resolving power. Commonly used commercial IMS systems provide resolving powers between 10 and 30; this new ion mobility spectrometer has resolving power greater than 60 for routine analysis. A high resolution instrument is necessary for many applications where a complex mixture needs to be separated and quantified. This paper demonstrates the advantages of using a high resolution ion mobility spectrometer and an electrospray ionization source for the analysis of non-volatile pharmaceuticals as well as dissolved explosive in solution phase.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available