The Central Dogma of Molecular Biology A Retrospective after Fifty Years

The Central Dogma of molecular biology was enunciated more than 50 years ago by Francis Crick to define the relations between the main informational macromolecules: DNA, RNA and proteins. Since that time, many disciplines have mimicked biology, and introduced their own 'Central Dogma'. This article is an attempt to review the status of the Central Dogma in the context of the new discoveries that were made during the past fifty years.