Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: A randomized study of cardiovascular effects and quality of life

Background Peak oxygen uptake (V-O2peak) strongly predicts mortality in cardiac patients. We compared the effects of aerobic interval training (AIT) versus moderate continuous training (MCT) on V-O2peak and quality of life after coronary artery bypass grafting (CABG). Methods Fifty-nine CABG patients were randomized to either AIT at 90% of maximum heart rate or MCT at 70% of maximum heart rate, 5 d/wk, for 4 weeks at a rehabilitation center. Primary outcome was V-O2peak, at baseline, after rehabilitation (4 weeks), and after 6 months of home-based exercise (6 months). Results V-O2peak increased between baseline and 4 weeks in AIT (27.1 +/- 4.5 vs 30.4 +/- 5.5 mL.kg(-1).min(-1), P < .001) and MCT (26.2 +/- 5.2 vs 28.5 +/- 5.6 mL.kg(-1).min(-1), P < .001; group difference, not significant). Aerobic interval training increased V-O2peak between 4 weeks and 6 months (30.4 +/- 5.5 vs 32.2 +/- 7.0 mL.kg(-1).min(-1), P < .001), with no significant change in MCT (28.5 +/- 5.6 vs 29.5 +/- 5.7 mL.kg(-1).min(-1)). Quality of life improved in both groups from baseline to 4 weeks, remaining improved at 6 months. There were no changes in echocardiographic systolic and diastolic left ventricular function. Adiponectin increased between 4 weeks and 6 months in both groups (group differences, not significant). Conclusions Four weeks of intense training increased V-O2peak significantly after both AIT and MCT. Six months later, the AIT group had a significantly higher V-O2peak than MCT. The results indicate that AIT and MCT increase V-O2peak similarly in the short term, but with better long-term effect of AIT after CABG. (Am Heart J 2009; 158: 1031-7.)