Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 184, Issue -, Pages 617-622Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2015.03.052
Keywords
Diabetes mellitus; Atrial fibrillation; Atrial remodeling; Upstream therapies
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Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation (AF) while AF is a strong and independent marker of overall mortality and cardiovascular morbidity in diabetic patients. Autonomic, electrical, electromechanical, and structural remodeling, including oxidative stress, connexin remodeling and glycemic fluctuations seem to be implicated in AF pathophysiology in the setting of DM. The present review highlights the association between DM and AF, provides a comprehensive overview of the responsible pathophysiological mechanisms and briefly discusses potential upstream therapies for DM-related atrial remodeling. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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