Journal
ALZHEIMERS & DEMENTIA
Volume 10, Issue 6, Pages 844-852Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.01.001
Keywords
Alzheimer's disease; Subjective cognitive decline; Preclinical Alzheimer's disease; Mild cognitive impairment; Prodromal Alzheimer's disease; Research criteria
Categories
Funding
- NCATS NIH HHS [UL1 TR001108] Funding Source: Medline
- NIA NIH HHS [P30 AG008051, R01 AG019771, K23 AG044431, P30 AG010133, R01 AG022374] Funding Source: Medline
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There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus. (C) 2014 The Alzheimer's Association. All rights reserved.
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