Journal
ALZHEIMERS & DEMENTIA
Volume 10, Issue 6, Pages 808-817Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.03.003
Keywords
Alzheimer's disease; Amyloid-beta peptides; Biomarkers; Cerebrospinal fluid; Standardization; Tau
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Funding
- corresponding governments within the BIOMARKAPD Project of the JPND
- Alzheimer Research Foundation (SAO-FRA)
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Background: Cerebrospinal fluid (CSF) biomarkers beta-amyloid 1-42 (A beta(1-42)), also expressed as A beta(1-42):A beta(1-40) ratio, T-tau, and P-tau(181P), have proven diagnostic accuracy for mild cognitive impairment and Alzheimer's disease (AD). How to use, interpret, and disclose biomarker results drives the need for standardization. Methods: Previous Alzheimer's Biomarkers Standardization Initiative meetings discussed preanalytical issues affecting A beta(1-42) and tau in CSF. This second round of consensus meetings focused on issues related to clinical use of AD CSF biomarkers. Results: Consensus was reached that lumbar puncture for AD CSF biomarker analysis be considered as a routine clinical test in patients with early-onset dementia, at the prodromal stage or with atypical AD. Moreover, consensus was reached on which biomarkers to use, how results should be interpreted, and potential confounding factors. Conclusions: Changes in A beta(1-42), T-tau, and P-tau(181P) allow diagnosis of AD in its prodromal stage. Conversely, having all three biomarkers in the normal range rules out AD. Intermediate conditions require further patient follow-up. (C) 2014 The Alzheimer's Association. All rights reserved.
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