Journal
JOURNAL OF ANXIETY DISORDERS
Volume 23, Issue 3, Pages 369-373Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.janxdis.2008.12.005
Keywords
Posttraumatic stress disorder; RGS2; Genetic by environment interaction; Candidate gene; Trauma
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Funding
- NIMH NIH HHS [MH 083469, R21 MH074469, K08-MH070627, K08 MH070627-05, K08 MH070627, R01 MH078928, MH078928, R21 MH074469-02, F32 MH083469, R01 MH078928-01A1, R01 MH078928-02, MH05220, F32 MH083469-01] Funding Source: Medline
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Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were found to be associated with anxious behavior in mice and anxiety in humans. We examined whether rs4606, a single nucleotide polymorphism (SNP) of RGS2, and social support moderated risk for PTSD in an epidemiologic sample. The study examines 607 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. rs4606 was associated with increased symptoms of posthurricane PTSD symptoms under conditions of high hurricane exposure and low social support (P < .05). Further, this polymorphism was associated with lifetime PTSD symptoms under conditions of lifetime exposure to a potentially traumatic event, and low social support (P < .001). These gene by environment interactions remained significant after adjustment for sex, ancestry, and age. RGS2 rs4606 modifies risk of postdisaster and lifetime PTSD symptoms under conditions of high stressor exposure. This is the first demonstration of gene-environment interaction for this locus. (C) 2008 Elsevier Ltd. All rights reserved.
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