Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 184, Issue -, Pages 9-13Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2015.02.015
Keywords
Carvedilol; Cancer; Beta-blocker; Taiwan National Health Insurance Research Database; Population-based cohort study
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Funding
- Tri-Service General Hospital [TSGH-C104-026]
- Taiwan Ministry of Science and Technology [MOST 103-2628-B-016-002-MY3]
- Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence [MOHW104-TDU-B-212-113002]
- China Medical University Hospital Cancer Research Center of Excellence, Taiwan [MOHW104-TD-B-111-03]
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Background: To investigate the effect of carvedilol on the incidence of cancer in a large population-based cohort study. Methods: Data were obtained from the Taiwan National Health Insurance Research Database. The cohort study included 6771 patients who received long-term carvedilol treatment between 2000 and 2010 (carvedilol cohort) and 6771 matched controls (noncarvedilol cohort). A Cox proportional hazards model was used to evaluate the risk of cancer in the patients treated with carvedilol. Results: With the mean follow-up period of 5.17 years and 4.93 years in the carvedilol and noncarvedilol cohorts, respectively, the patients in the carvedilol cohort had a 26% reduction of cancer risk compared with those in the noncarvedilol cohort (hazard ratio [HR] = 0.74; 95% confidence interval [CI] = 0.63-0.87; p < .001). The sex-specific carvedilol to noncarvedilol relative risk was lower for both women (HR = 0.73; 95% CI = 0.56-0.94) and men (HR = 0.75; 95% CI = 0.61-0.92). Moreover, stratified by cancer site, treatment with carvedilol in the carvedilol cohort resulted in significantly lower incidence of stomach and lung cancers than in the noncarvedilol cohort. Conclusion: This nationwide population-based cohort study demonstrated that long-termtreatment with carvedilol is associated with reduced upper gastrointestinal tract and lung cancer risk, indicating that carvedilol could be a potential agent in these cancers prevention. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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