Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 4, Pages 235-245Publisher
NATURE RESEARCH
DOI: 10.1038/nri2524
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Funding
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases
- National Institutes of Health, USA
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In recent years, intense research efforts have been dedicated to elucidating the pathogenic mechanisms of HIV-associated disease progression. In addition to the progressive depletion and dysfunction of CD4(+) T cells, HIV infection also leads to extensive defects in the humoral arm of the immune system. The lack of immune control of the virus in almost all infected individuals is a great impediment to the treatment of HIV-associated disease and to the development of a successful HIV vaccine. This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction.
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