Journal
NATURE REVIEWS CANCER
Volume 9, Issue 4, Pages 285-293Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2621
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Funding
- Kay Kendall Leukaemia Fund Travelling Fellowship
- Fulbright Scholarship in Cancer Research
- National Cancer Institute [RO1CA098234]
- National Foundation
- Emerald Foundation
- Malcolm Hewitt Wiener Foundation
- Nancy C. and Daniel P. Paduano Foundation
- American Hellenic Educational Progressive Association
- Charles and Meryl Witmer Family Foundation
- Butler Foundation
- Children's Cancer and Blood Foundation
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The 'seed and soil' hypothesis for metastasis sets forth the concept that a conducive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion presents emerging data that support this concept and outlines the potential mechanism and temporal sequence by which changes occur in tissues distant from the primary tumour. To enable improvements in the prognosis of advanced malignancy, early interventions that target both the disseminating seed and the metastatic soil are likely to be required.
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