Journal
ALZHEIMERS & DEMENTIA
Volume 6, Issue 3, Pages 239-246Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2010.03.006
Keywords
Alzheimer's disease; ADNI; Clinical trials
Categories
Funding
- National Institute on Aging of the National Institutes of Health [U01-AG024904, U01-AG10483]
- NATIONAL INSTITUTE ON AGING [U19AG010483, U01AG024904, U01AG010483] Funding Source: NIH RePORTER
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The Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has provided clinical, operational. and data management support to ADNI since its inception This article reviews the activities and accomplishments of the core in support of ADNI aims These include the enrollment and follow-up of than 800 subjects in die three original cohorts healthy controls. amnestic mild cognitive impairment (now referred to as late MCI. or LMCI). and mild Alzheimer's disease (AD) in the first phase of ADNI (ADNI). with baseline longitudinal. clinical. and cognitive assessments These data. when combined with genetic. neuroimaging. and cerebrospinal fluid measures. have provided important insights into the neurobiology of the AD spectrum Furthermore. these data have facilitated the development of novel clinical trial designs. ADNI has recently been extended with funding from an NIH Grand Opportunities (GO) award. and the new ADNI GO phase has been launched: this includes the enrollment of a new cohort. called early MCI. with milder episodic memory impairment than the LMCI group An application for a further 5 years of ADNI funding (ADNI 2) was recently submitted. This funding would support ongoing follow-up of the original ADNI 1 and ADNI GO cohorts, as well as additional recruitment into all categories The resulting data would provide valuable data on the earliest stages of AD and support the development of interventions in these critically important populations (C) 2010 The Alzheimer's Association All rights reserved
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