Journal
ALZHEIMERS & DEMENTIA
Volume 6, Issue 1, Pages 1-10Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2009.10.003
Keywords
Alzheimer's disease; Nutritional intervention; Synapse formation; Membrane phosphatide synthesis; B vitamins; Omega-3 fatty acids; Nucleotides; Uridine; Phospholipids; Choline; Antioxidants; ADAS-cog, delayed verbal recall; Medical food; Dietary management; Randomized clinical trial; Dementia
Categories
Funding
- Danone Research-Centre for Specialised Nutrition
Ask authors/readers for more resources
Objective: To investigate the effect of a medical food on cognitive function in people with mild Alzheimer's disease (AD). Methods: A total of 225 drug-naive AD patients participated in this randomized, double-blind controlled trial. Patients were randomized to active product, Souvenaid, or a control drink, taken once-daily for 12 weeks. Primary outcome measures were the delayed verbal recall task of the Wechsler Memory Scale-revised, and the 13-item modified Alzheimer's Disease Assessment Scale-cognitive subscale at week 12. Results: At 12 weeks, significant improvement in the delayed verbal recall task was noted in the active group compared with control (P=.021). Modified Alzheimer's Disease Assessment Scale-cognitive subscale and other outcome scores (e.g., Clinician Interview Based Impression of Change plus Caregiver Input, 12-item Neuropsychiatric Inventory, Alzheimer's disease Co-operative Study-Activities of Daily Living, Quality of Life in Alzheimer's Disease) were unchanged. The control group neither deteriorated nor improved. Compliance was excellent (95%) and the product was well tolerated. Conclusions: Supplementation with a medical food including phosphatide precursors and cofactors for 12 weeks improved memory (delayed verbal recall) in mild AD patients. This proof-of-concept study justifies further clinical trials. (C) 2010 The Alzheimer's Association. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available