Journal
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
Volume 23, Issue 3, Pages 295-297Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WAD.0b013e31819c5ef4
Keywords
Parkinson disease with dementia; Alzheimer disease; dementia with Lewy bodies; assessment of dementia; senile plaques; neurofibrillary tangles; dementia; Parkinson disease
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Funding
- Sun Health Research Institute Brain Donation Program
- Arizona Parkinson's Disease Consortium
- Michael J. Fox Foundation for Parkinson's Research (The Prescott Family Initiative)
- Arizona Biomedical Research Commission [4001, 0011, 05-901]
- National Institute on Aging [P30 AG19610]
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Subjects with Parkinson disease (PD) frequently develop dementia with greater than one-third meeting neuropathologic diagnostic criteria for Alzheimer disease (AD). The objective is to identify clinical and neuropathologic differences between Parkinson disease with dementia (PDD) subjects, with and without coexistent AD pathology. Neuropathologic examination was available on subjects diagnosed by clinicopathologic criteria with PDD - AD (N = 23) and PDD + AD (N = 28). A small subset of subjects with PDD - AD and PDD + AD had received at least 1 standardized neuropsychologic assessment. PDD + AD subjects were significantly older at age of PD onset and death, progressed to onset of dementia in less time, and had a shorter duration of PD symptoms before the onset of dementia. Education, responsiveness Of L-dopa and dopaminergic medications, presence of cognitive fluctuations and hallucinations, and mean Mini-Mental State Examination, Global Deterioration Scale, Functional Assessment Staging, and Unified Parkinson Disease Rating Scale scores did not differ significantly between the 2 groups. The PDD + AD group had significantly greater total plaques, neuritic plaques, total tangles, and Braak stages compared with PDD - AD. This study suggests that it is difficult to distinguish PDD + AD and PDD - AD on the basis of movement, clinical, and neuropsychologic assessment. PDD - AD and PDD + AD have similar degrees of dementia and approximately half of PDD subjects have enough AD pathology to attain a neuropathologic diagnosis of AD. PDD can develop in the absence of significant Alzheimer pathology.
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