Journal
ALLERGY
Volume 65, Issue 8, Pages 996-1003Publisher
WILEY
DOI: 10.1111/j.1398-9995.2009.02307.x
Keywords
CD8+T cell; CTL; DTH; effector T cell; penicillin; murine model; regulatory T cells
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Universite Claude Bernard (UCB) Lyon 1
- La Fondation pour la Recherche Medicale (FRM)
- Societe Francaise de Dermatologie
- Societe Francaise d'Allergologie et Immunologie Clinique
- Societe de Recherche Dermatologique
Ask authors/readers for more resources
P>Background: Delayed allergic skin reactions to drugs are common iatrogenic diseases mediated by activation of specific T cells in the skin. Methods: To better understand the role of T cells in these diseases, we developed a mouse model of drug allergy induced by skin sensitization to amoxicillin (amox), a penicillin antibiotic frequently involved in delayed drug allergy. Results: Whereas wild-type mice could not be sensitized to amox, CD4+ T-cell-deficient mice developed an amox-specific allergic skin response, mediated by IFN-gamma-producing CD8+ T cells. Amox-specific CD8+ T cells, induced in lymphoid organs at a high frequency during sensitization, were recruited in the skin upon challenge. CD8+ T cells were effectors of the allergic skin reaction to amox as in vivo treatment with depleting anti-CD8 mAbs abrogated the skin inflammatory reaction and as purified CD8+ T cells could adoptively transfer the allergic response to naive recipients. Conclusion: CD8+ T cells mediate penicillin skin allergy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available