Journal
ALLERGY
Volume 64, Issue 9, Pages 1333-1341Publisher
WILEY
DOI: 10.1111/j.1398-9995.2009.02006.x
Keywords
asthma; environmental exposures; genetic risk factors; respiratory diseases
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Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. Results: For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (P-interaction = 0.004), itchy rash < 12 mo (P-interaction = 0.001) and dry cough at night in the past 12 months (< 12 months) (P-interaction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (P-interaction = 0.006), rhinitis < 12 mo (P-interaction = 0.004), and marginally significant for ever hayfever (P-interaction = 0.07), allergic eye symptoms < 12 mo (P-interaction = 0.09); their risk allele was G in Russians and A in Finns. Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women.
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