4.7 Review

The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents

Related references

Note: Only part of the references are listed.
Review Genetics & Heredity

Metabolic modulation of cancer: a new frontier with great translational potential

Adam Kinnaird et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

Article Biochemistry & Molecular Biology

Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate

Rakesh K. Pathak et al.

ACS CHEMICAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

Ozkan Ozden et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Article Biochemistry & Molecular Biology

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

Shih-Chia Tso et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Tyr-301 Phosphorylation Inhibits Pyruvate Dehydrogenase by Blocking Substrate Binding and Promotes the Warburg Effect

Jun Fan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth

Changliang Shan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Cell Biology

Comprehensive review on lactate metabolism in human health

M. Adeva-Andany et al.

MITOCHONDRION (2014)

Review Biochemistry & Molecular Biology

Influence of Metabolism on Epigenetics and Disease

William G. Kaelin et al.

Article Biochemistry & Molecular Biology

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

Jeongsoon Park et al.

MOLECULAR CELL (2013)

Article Cell Biology

Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis

Rosa Ferriero et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Pharmacology & Pharmacy

Clinical and Experimental Applications of Sodium Phenylbutyrate

Tommaso Iannitti et al.

Drugs in research & development (2013)

Article Oncology

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

Tanupriya Contractor et al.

CANCER RESEARCH (2012)

Review Cell Biology

Metabolic Regulation of Epigenetics

Chao Lu et al.

CELL METABOLISM (2012)

Article Biochemistry & Molecular Biology

Glucose Oxidation Modulates Anoikis and Tumor Metastasis

Sushama Kamarajugadda et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Cell Biology

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

Alexandra R. Grassian et al.

GENES & DEVELOPMENT (2011)

Review Oncology

Anticancer drugs that target metabolism: is dichloroacetate the new paradigm?

Ioanna Papandreou et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

Article Biochemistry & Molecular Biology

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

Taro Hitosugi et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

Shanta Dhar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

Kathryn E. Wellen et al.

SCIENCE (2009)

Review Pharmacology & Pharmacy

Role of dichloroacetate in the treatment of genetic mitochondrial diseases

Peter W. Stapoole et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

Review Oncology

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

E. D. Michelakis et al.

BRITISH JOURNAL OF CANCER (2008)

Article Biochemistry & Molecular Biology

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

R. Max Wynn et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Regulation of the PDK4 isozyme by the Rb-E2F1 complex

Michael C. F. Hsieh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

Thomas McFate et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

Chun-Wun Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

T. E. Roche et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Article Biotechnology & Applied Microbiology

Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

Heidi Lyng et al.

BMC GENOMICS (2006)

Article Biochemistry & Molecular Biology

Regulation of the pyruvate dehydrogenase complex

MS Patel et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2006)

Article Biochemistry & Molecular Biology

Structure of pyruvate dehydrogenase kinase - Novel folding pattern for a serine protein kinase

CN Steussy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)