Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 138, Issue 4, Pages 809-817Publisher
WILEY
DOI: 10.1002/ijc.29564
Keywords
pyruvate dehydrogenase complex; pyruvate dehydrogenase kinase; pyruvate dehydrogenase phosphatase; Warburg effect; cancer metabolism; PDK inhibitors
Categories
Funding
- Universite Paris Descartes
- INSERM [U1124, ITM0-cancer]
Ask authors/readers for more resources
Cancer cells exhibit an altered metabolism which is characterized by a preference for aerobic glycolysis more than mitochondrial oxidation of pyruvate. This provides anabolic support and selective growth advantage for cancer cells. Recently, a new concept has arisen suggesting that these metabolic changes may be due, in part, to an attenuated mitochondrial function which results from the inhibition of the pyruvate dehydrogenase complex (PDC). This mitochondrial complex links glycolysis to the Krebs cycle and the current understanding of its regulation involves the cyclic phosphorylation and dephosphorylation by specific pyruvate dehydrogenase kinases (PDKs) and pyruvate dehydrogenase phosphatases (PDPs).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available