Journal
SLEEP MEDICINE CLINICS
Volume 4, Issue 2, Pages 165-+Publisher
ELSEVIER INC
DOI: 10.1016/j.jsmc.2009.01.004
Keywords
Biological rhythm; Core body temperature; Illuminance; Melatonin; Phase-response curve
Categories
Funding
- NCCIH NIH HHS [R21 AT002571-02, R21 AT002571, R21 AT002571-03, R21 AT002571-01] Funding Source: Medline
- NCRR NIH HHS [M01 RR002635-200670, M01 RR002635-235404, M01 RR002635-245548, M01 RR002635-210670, M01 RR002635-245545, M01 RR002635-225377, M01 RR002635-245588, M01 RR002635-235401, M01 RR002635-225374, M01 RR002635] Funding Source: Medline
- NHLBI NIH HHS [R01 HL077453, R01 HL080978-02, R01 HL077453-03, R01 HL080978, R01 HL080978-01A1, F32 HL008978, R01 HL077453-02, R01 HL077453-01, R01 HL077453-04, R01 HL080978-03, R01 HL080978-04] Funding Source: Medline
- NIA NIH HHS [P01 AG009975-130001, P01 AG009975-10S1, P01 AG009975-100001, P01 AG009524, P01 AG009975-070001, R01 AG006072-20, P01 AG009975-130007, P01 AG009975-12, P01 AG009975-13, P01 AG009975-10, R01 AG006072, R01 AG006072-12, R01 AG006072-17, P01 AG009975-110007, P01 AG009975-090001, R01 AG006072-13, P01 AG009975-120007, P01 AG009975-08, R01 AG006072-15, P01 AG009975-11, R01 AG006072-19, R01 AG006072-16A1, P01 AG009975-060001, P01 AG009975-120001, P01 AG009975-06, P01 AG009975-080001, P01 AG009975-07, P01 AG009975-110001, P01 AG009975, R01 AG006072-14, P01 AG009975-09, R01 AG006072-18, R01 AG053952] Funding Source: Medline
- NIMH NIH HHS [R01 MH045130, R01 MH045130-14, R01 MH045130-17, R01 MH045130-13, R01 MH045130-15, R01 MH045130-12, R01 MH045130-10, R01 MH045130-11A1, R01 MH045130-16A1] Funding Source: Medline
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The circadian system in animals and humans, being near but not exactly 24 hours in cycle length, must be reset on a daily basis to remain in synchrony with external environmental time. This process of entrainment is achieved in most mammals through regular exposure to light and darkness. In this article, we review the results of studies over the past 25 years conducted in our laboratory and in those of others investigating the effects of light on the human circadian timing system. These studies have revealed how the timing, intensity, duration, and wavelength of light affect the human biologic clock. Our most recent studies also demonstrate that much is yet to be learned about the effects of light on the human circadian timing system.
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