Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 138, Issue 1, Pages 14-21Publisher
WILEY
DOI: 10.1002/ijc.29417
Keywords
extracellular vesicles; exosomes; mesenchymal stem cells; microRNA; MSCs; Lipids; proteins; RNA; tumor microenvironment
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Funding
- NCI NIH HHS [R01 CA151851] Funding Source: Medline
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In recent years, the knowledge about the control of tumor microenvironment has increased and emerged as an important player in tumorigenesis. The role of normal stromal cells in the tumor initiation and progression has brought our vision in to the forefront of cell-to-cell communication. In this review, we focus on the mechanism of communication between stromal and tumor cells, which is based on the exchange of extracellular vesicles (EVs). We describe several, evergrowing, pieces of evidence that EVs transfer messages through their miRNA, lipid, protein and nucleic acid contents. A better understanding of this sophisticated method of communication between normal cancer cells may lead to developing novel approaches for personalized diagnostics and therapeutics.
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