Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 138, Issue 1, Pages 22-29Publisher
WILEY
DOI: 10.1002/ijc.29443
Keywords
innate lymphoid cells; cytokine; cancer; Th1; Th2; IL-17; IL-22
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Funding
- Major State Basic Research Development Program of China [2013CB531503]
- National Natural Science Foundation of China [31170839, 30930086]
- Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT 10521]
- NSFC Major Collaborative Project [81220108024]
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Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-tumor immune-related function was recently demonstrated. In this review we discuss whether and how ILCs involve in the tumorigenesis, providing new insights into the mechanisms underlying the particular functions of ILCs as well as the potential targets for tumor intervention.
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