Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 8, Pages 4990-4997Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b00175
Keywords
poly(cyclotriphosphazeno-co-fluorescein) (PCTPF); nanoshells; fluorescence; doxorubicin (DOX); drug delivery
Funding
- National Science Foundation for Distinguished Young Scholars [50925310]
- National Science Foundation of China [21174087, 21474079]
- Major Project of Chinese National Programs for Fundamental Research and Development (973 Project) [2009CB930400]
- Program for New Century Excellent Talents in University [NCET-13-0453]
- China Postdoctoral Science Foundation [18420011, 2014T70909]
- Fundamental Funds for the Central Universities [08142027, 08143101]
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Functionalized and monodisperse nanoshells have attracted significant attention owing to their well-defined structure, unique properties, and wide range of potential applications. Here, the synthesis of cross-linked organic-inorganic hybrid nanoshells with strong fluorescence properties was reported via a facile precipitation polymerization of hexachlorocyclotriphosphazene (HCCP) and fluorescein on silica particles used as templates. The resulting poly(cyclotriphosphazene-co-fluorescein) (PCTPF) nanoshells were firm cross-linked shells with similar to 2.2 nm mesopores that facilitated the transport of drug molecules. The fluorescent nanoshells also exhibited excellent water dispersibility and biocompatibility; thus, they can be considered as ideal drug vehicles with high doxorubicin storage capacity (26.2 wt %) and excellent sustained release (up to 14 days). Compared to doxorubicin (DOX) alone, the PCTPF nanoshells more efficiently delivered DOX into and killed cancer cells. Moreover, the PCTPF nanoshells also exhibited remarkable fluorescent emission properties and improved photobleaching stability in both suspension and solid state owing to the covalent immobilization of fluorescein in the highly cross-linked organic-inorganic hybrids. The exceptional fluorescent properties enabled the release of DOX as well as the distribution of nanoshells and DOX to be monitored.
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