Journal
CLINICAL LYMPHOMA & MYELOMA
Volume 9, Issue 3, Pages 206-216Publisher
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2009.n.042
Keywords
Classical Hodgkin's lymphoma; Epstein-Barr virus; HIV; Immunophenotype; Nodular lymphocyte-predominant disease; Primary mediastinal large B-cell lymphoma
Categories
Funding
- Center for Cancer Research, National Cancer Institute
Ask authors/readers for more resources
In the past few years, there has been a greater understanding of the spectrum and biology of Hodgkin lymphoma (HL). In standard texts, HL is classified as 2 distinct entities, namely nodular lymphocyte-predominant HL and classical HL (CHL). However, recent evidence suggests that CHL is not a single disease. Although the mixed cellularity and lymphocyte-depleted subtypes might be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology. Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available