Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 72, Issue -, Pages 282-289Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2014.08.029
Keywords
Carbohydrate-based drug; Cartilage; Eye drop; Glycosaminoglycan; Keratan sulfate; Inflammation
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [Universal-14/2013-[470330/2013-9]]
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/110.961/2013]
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Keratan sulfate (KS) is a glycosaminoglycan (GAG) type consisted of a sulfated poly-N-acetyl lactosamine chain. Besides acting as a constitutive molecule of the extracellular matrices, this GAG also plays a role as a hydrating and signaling agent in cornea and cartilage tissues. Inasmuch, KS is widely explored in the pharmaceutical industry. This review will cover the major achievements described in the literature of 2010-2014 concerning this GAG. Discussion about KS' roles in physiopathological conditions, as target or therapeutic molecule in diseases, methods of analysis and detection as well as KS-related enzymes, metabolism and developmental biology is properly provided. (C) 2014 Elsevier B.V. All rights reserved.
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