Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 74, Issue -, Pages 620-626Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2014.12.024
Keywords
Chitosan; Nanocomposite hydrogel; Kaolin; EWC; Biodegradability; Grafting
Funding
- DST-PURSE Scheme, Govt. of India
- Council of Scientific and Industrial Research (CSIR), New Delhi, India [JRF: 09/173(0131)/2013-EMR-I]
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Chitosan, a natural biopolymer, obtained by alkaline deacetylation of chitin, exhibits excellent biological properties such as biodegradability, immunological and antibacterial activity. Recently, there has been a growing interest in the chemical modification of chitosan in order to widen its applications. The chemical modification of chitosan has been achieved via grafting of monomer, 2-hydroxyethyl methacrylate (HEMA) in the presence of the initiator, ammonium persulfate (APS) and kaolin was added to improve the mechanical strength of the newly developed nanocomposites hydrogel. The so prepared grafted nanocomposites hydrogel was characterized by FTR, XRD, SEM, TEM and TGA. The equilibrium water content (EWC) of the samples were measured at different pH ranges 6.5-8.0 and found optimum at pH 7.5 for biomedical applications. Further, the biodegradability of the samples was studied at different time intervals from 15 days to 1 year but, the kaolin based nanohydrogels exhibited good biodegradability. (C) 2015 Elsevier B.V. All rights reserved.
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