Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 72, Issue -, Pages 466-471Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2014.08.020
Keywords
N,N,N-trimethyl chitosan; Alginate; Beads; Polyelectrolyte complex; Gold nanoparticles
Funding
- CNPq/CAPES, Brazil [Proc. 481424/2010-5, Proc. 308337/2013-1]
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Polyelectrolyte complex beads based on N,N,N-trimethyl chitosan (TMC) and sodium alginate (ALG) were obtained. This biomaterial was characterised by FTIR, TGA/DTG, DSC and SEM analysis. The good properties of polyelectrolyte complex hydrogel beads were associated, for the first time, with gold nanoparticles (AuNPs). Through a straightforward methodology, AuNPs were encapsulated into the beads. The in vitro cytotoxicity assays on the Caco-2 colon cancer cells and healthy VERO cells showed that the beads presented good biocompatibility on both cell lines, whereas the beads loaded with gold nanoparticles (beads/AuNPs) was slightly cytotoxic on the Caco-2 and VERO cells. (C) 2014 Elsevier B.V. All rights reserved.
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