Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 75, Issue -, Pages 90-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.01.023
Keywords
Pleurotus sajor-caju; Exopolysaccharide; Mannogalactan
Funding
- Brazilian funding agency CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- Brazilian funding agency CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- Brazilian funding agency FINEP (Financiadora de Estudos e Projetos)
- Brazilian funding agency FAP (Fundo de Apoio a Pesquisa)/UNIVILLE
- Brazilian funding agency Fundacao Araucaria
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Edible mushrooms are high nutritional value foods, which contain proteins, fibers, minerals, vitamins, and carbohydrates. Among their carbohydrates are some polysaccharides with recognized therapeutic effects. It was reported in this manuscript the structural characterization and antinociceptive and anti-inflammatory activities of an exopolysaccharide (EPS) produced by Pleurotus sajor-caju. The purified EPS was a mannogalactan (PEIsR), which was composed by mannose (37.0%), galactose (39.7%), and 3-O-methyl-galactose (23.3%). The polysaccharide was purified by freeze-thawing and dialysis, and it was characterized by GC-MS analysis and NMR spectroscopy. The mannogalactan is constituted by a main chain of (1 -> 6)-linked alpha-D-Galp and 3-O-methyl-alpha-D-Galp units. Some of the alpha-D-Galp units were substituted at 0,2 by non-reducing end units of beta-D-Manp. According to the literature review conducted, this is the first time that a methylated polysaccharide was observed on EPS of P. sajor-caju. The mannogalactan was able to reduce the nociception, in vivo, in the writhing and formalin tests and also reduced the carrageenan-induced paw edema, which indicates that it could be an effective antinociceptive and anti-inflammatory agent. (C) 2015 Published by Elsevier B.V.
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