Journal
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Volume 34, Issue 1, Pages 4-18Publisher
WILEY
DOI: 10.1111/j.1530-0277.2009.01060.x
Keywords
Fibrosis; Liver Disease; Pancreas; Lung; Bacterial and Viral Infection
Categories
Funding
- National Health and Medical Research Council (NHAMP
- MRC) of Australia
- NIH, NIAAA [R01AA013168]
- NHMRC
- Cancer Council of New South Wales, Australia (Apte)
- CIBEREHD [P1070193]
- Instituto de Salud Carlos III, Spain [P50-AA-11999]
- U.S. National Institute on Alcohol Abuse and Alcoholism
- BMBF (HepatoSys)
- European Alcohol Research Foundation (ERAB) (Dooley)
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA013168] Funding Source: NIH RePORTER
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Alcohol is recognized as a direct hepatotoxin. but the precise molecular pathways that are important for the initiation and progression of alcohol-induced tissue injury are not completely understood. The current understanding of alcohol toxicity to organs suggests that alcohol initiates injury by generation of oxidative and nonoxidative ethanol metabolites and via translocation of gut-derived endotoxin. These processes lead to cellular injury and stimulation of the inflammatory responses mediated through a variety of molecules. With continuing alcohol abuse, the injury progresses through impairment of tissue regeneration and extracellular matrix (ECM) turnover, leading, to fibrogenesis and cirrhosis. Several cell types Lire involved in this process, the predominant being stellate cells, macrophages, and parenchymal cells. In response to alcohol, growth factors and cytokines activate many signaling cascades that regulate fibrogenesis. This mini-review brings together research focusing on the underlying mechanisms of alcohol-mediated injury in a number of organs. It highlights the various processes and molecules that are likely involved in inflammation, immune modulation, susceptibility to infection, ECM turnover and fibrogenesis in the liver, pancreas, and lung triggered by alcohol abuse.
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