Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 78, Issue -, Pages 202-208Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2015.04.008
Keywords
Runx2; Phosphorylation; Osteoblast; Bone
Funding
- Department of Science and Technology, Science and Engineering Research Board (DST-SERB), India [SR/SO/HS-181/2013]
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Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events via posttranslational modifications. Hence, in this review we summarized the structural integrity of Runx2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis. (C) 2015 Elsevier B.V. All rights reserved.
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