Journal
ALCOHOL
Volume 43, Issue 4, Pages 265-269Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.alcohol.2009.04.003
Keywords
Alcohol dependence; Nerve growth factor; Brain-derived neurotrophic factor; Neurotrophin; Plasma; ELISA
Categories
Funding
- Hallym University Medical Center Research Fund [01-2006-02]
Ask authors/readers for more resources
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are thought to be related to neuroprotection in cell culture and animal studies. Our aim was to verify the changes in human plasma BDNF and NGF concentrations induced by chronic alcohol use. Forty-one male patients with alcohol dependence were sampled the next morning of admission and compared with 41 healthy male subjects. Plasma BDNF and NGF were assayed using an enzyme-linked immunosorbent assay (ELISA). Mean plasma BDNF level was significantly higher in the patients with alcohol dependence (3502.21 +/- 1726.9 pg/mL) compared with the healthy subjects (861.75 +/- 478.9 pg/mL) (P = .000). Mean plasma NGF level was also significantly higher in patients with alcohol dependence, (137.64 +/- 32.7 pg/mL) than in healthy subjects (112.61 +/- 90.2 pg/mL) (P = .012). Plasma BDNF and NGF levels showed significant negative correlation in alcohol dependence group (r = -0.388, P = .012). Increased plasma BDNF and NGF with negative correlation in alcohol-dependent patients may have some role in the regeneration of damage done by chronic alcohol use. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available