Journal
ALCOHOL
Volume 42, Issue 6, Pages 487-492Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.alcohol.2008.05.006
Keywords
ethanol dependence; opioid system; swim stress-induced analgesia; chronic mild stress; selected mouse lines
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Funding
- Polish Committee for Scientific Research (KBN) [2P05A13029]
- Sixth European Framework Programme [LSHM-CT-2004-503474]
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Alcoholism is a complex disorder, still not fully understood, in which environmental and inherited risk factors play essential roles. Of particular importance may be chronic exposure to stress thought to increase preference for ethanol in genetically susceptible individuals. Animal and human data suggest that the opioid system may be involved in the development of alcohol dependence. We studied the effects of chronic mild stress (CMS) on the voluntary intake of 8% ethanol in the mouse lines displaying high (HA) or low (LA) swim stress-induced analgesia. These lines differ in the activity of the endogenous opioid system. Normally, 8% ethanol is aversive to rodents. We found that LA mice with the low opioid system activity exposed to CMS manifested greater ethanol intake than under no stress conditions. No such effect of CMS on ethanol consumption was observed in HA mice that display the enhanced opioid system activity. We conclude that CMS imposed on individuals with a genetically determined low opioid activity may favor the development of ethanol abuse. (C) 2008 Elsevier Inc. All rights reserved.
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