Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 80, Issue -, Pages 48-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.06.022
Keywords
Gold nanoparticles; Gum karaya; Biocompatibility; Gemcitabine hydrochloride; Anticancer activity
Funding
- CSIR-New Delhi grant under project Advance Drug Delivery [ADD-CSC 0302]
- Council of Scientific and Industrial Research (CSIR), New Delhi
- IICT-RMIT Joint Research centre
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Biocompatibility is one of the major concerns with inorganic nanoparticles for their applications as drug delivery system. Natural compounds such as sugars, hydrocolloids and plant extracts have shown potential for the green synthesis of biocompatible gold nanoparticles. In this study, we report the synthesis of gum karaya (GK) stabilized gold nanoparticles (GKNP) and the application of prepared nanoparticles in the delivery of anticancer drugs. GKNP were characterized using different analytical techniques. GKNP exhibited high biocompatibility during cell survival study against CHO normal ovary cells and A549 human non-small cell lung cancer cells and during hemolytic toxicity studies. Gemcitabine hydrochloride (GEM), an anticancer drug, was loaded on the surface of nanoparticles with 19.2% drug loading efficiency. GEM loaded nanoparticles (GEM-GNP) showed better inhibition of growth of cancer cells in and-proliferation and clonogenic assays than native GEM. This effect was correlated with higher reactive oxygen species generation by GEM-GNP in A549 cells than native GEM. In summary, GK has significant potential in the synthesis of biocompatible gold nanoparticles that could be used as prospective drug delivery carrier for anticancer drugs. (C) 2015 Elsevier B.V. All rights reserved.
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