Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 78, Issue -, Pages 72-78Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2015.03.061
Keywords
Cell encapsulation; Hydrogel; Alginate
Funding
- Emerging Fields Initiative (EFI) of the University of Erlangen-Nuremberg, Germany
- German Academic Exchange Service (DAAD)
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Hydrogel-based biomaterials are ideal scaffolding matrices for microencapsulation, but they need to be modified to resemble the mechanical, structural and chemical properties of the native extracellular matrix. Here, we compare the mechanical properties and the degradation behavior of unmodified and modified alginate hydrogels in which cell adhesive functionality is conferred either by blending or covalently cross-linking with gelatin. Furthermore, we measure the spreading and proliferation of encapsulated osteoblast-like MG-63 cells. Alginate hydrogels covalently crosslinked with gelatin show the highest degree of cell adhesion, spreading, migration, and proliferation, as well as a faster degradation rate, and are therefore a particularly suitable material for microencapsulation. (C) 2015 Elsevier B.V. All rights reserved.
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