Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 79, Issue -, Pages 217-225Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.04.073
Keywords
Nitric oxide-releasing film; Antibacterial activity; Wound healing
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2014R1A1A4A01007808]
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HI12C0529010013]
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Nitric oxide (NO) is a promising therapeutic agent with antibacterial and wound-healing properties. However, the gaseous state and short half-life of NO necessitate a formulation that can control its storage and release. In this study, we developed NO-releasing films (CS/NO film) composed of chitosan (CS) and S-nitrosoglutathione (GSNO) as a NO donor. Thermal analysis demonstrated molecular dispersion of GSNO in the films. In vitro release study revealed that NO release from CS/NO films followed Korsmeyer-Peppas model with Fickian diffusion kinetics. Moreover, the CS/NO film showed a stronger antibacterial activity against Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive) than the CS film. Further, the CS/NO film accelerated wound healing and epithelialization in a rat model of full-thickness wounds as compared to the CS film. Histopathological studies revealed that CS/NO films favorably enhanced the re-epithelialization and reconstruction of wounded skin. Therefore, our results suggest that CS/NO films could be a suitable formulation for treating full-thickness wounds. (C) 2015 Elsevier B.V. All rights reserved.
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