Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 72, Issue -, Pages 47-53Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2014.07.054
Keywords
Alginate; Locust bean gum; Microspheres; Sustained drug delivery; Anti-inflammatory activity
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The alginate microspheres represent a useful tool for sustained oral delivery of drugs but exhibit several problems associated with the stability and rapid release of drugs at higher pH values. To overcome these drawbacks, alginate-locust bean gum (LBG) interpenetrating microspheres were prepared by calcium ion (Ca+2) induced ionotropic gelation technique for prolonged release of aceclofenac. The drug entrapment efficiency of these microspheres was found to be 59-93%. The microspheres lied in the size range of 406-684 mu m. Scanning electron microscopy revealed spherical shape of the microspheres. No drug-polymer interaction was evident after infrared spectroscopy analysis. The microspheres provided sustained release of aceclofenac in phosphate buffer solution (pH 6.8) over a period of 8 h. The drug release data were fitted into the Korsmeyer-Peppas model and the drug release was found to follow anomalous (non-Fickian) diffusion mechanism. Pharmacodynamic study of the microspheres showed a prolonged anti-inflammatory activity in carrageenan-induced rat paw model following oral administration. (C) 2014 Published by Elsevier B.V.
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