Journal
NATURE REVIEWS CANCER
Volume 9, Issue 7, Pages 476-488Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2674
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Funding
- NCI NIH HHS [CA-81301, R37 CA081301, CA-102502, CA-128801, R01 CA102502, R01 CA128801] Funding Source: Medline
- NIDA NIH HHS [P50 DA013333, DA-13333] Funding Source: Medline
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Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.
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