Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 62, Issue -, Pages 142-146Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2015.03.007
Keywords
WNT1 inducible signaling pathway protein 1; WISP; CCN; Cancer; Metastasis
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Funding
- Swiss National Science Foundtion [NF31003A_120235, NF31003A_135584]
- Swiss Cancer League [KFS-2980-08-2012]
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The matricellular protein WISP1 is a member of the CCN protein family. It is induced by WNT1 and is a downstream target of beta-catenin. WISP1 is expressed during embryonic development, wound healing and tissue repair. Aberrant WISP1 expression is associated with various pathologies including osteoarthritis, fibrosis and cancer. Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors. 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
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